Drug interactions
Methamphetamine + Yohimbine
Severity: Major
Methamphetamine and Yohimbine: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance adrenergic activity, so combined use can produce marked rises in blood pressure and heart rate, along with anxiety, tremor and agitation. Patients with cardiovascular disease are at particular risk of hypertensive episodes or arrhythmias.
What this interaction means in plain words
Methamphetamine and Yohimbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive sympathomimetic effects: methamphetamine releases norepinephrine and yohimbine blocks presynaptic alpha-2 receptors, increasing norepinephrine release.
What to do
Avoid combining where possible, especially in patients with hypertension or heart disease. If it cannot be avoided, monitor blood pressure and heart rate and watch for agitation or palpitations.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Yohimbine?
MediHelp rates the interaction as major. Methamphetamine and Yohimbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs enhance adrenergic activity, so combined use can produce marked rises in blood pressure and heart rate, along with anxiety, tremor and agitation. Patients with cardiovascular disease are at particular risk of hypertensive episodes or arrhythmias.
How serious is the interaction between Methamphetamine and Yohimbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, especially in patients with hypertension or heart disease. If it cannot be avoided, monitor blood pressure and heart rate and watch for agitation or palpitations.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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