Drug interactions
Methocarbamol + Sufentanil
Severity: Major
Methocarbamol and Sufentanil: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a very potent opioid, and methocarbamol adds to sedation. The combination can cause profound sedation and respiratory depression, particularly in non-monitored settings.
What this interaction means in plain words
Methocarbamol and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methocarbamol belongs to Musculoskeletal; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression.
What to do
Use only with continuous monitoring of sedation and respiratory status, and reduce doses as needed. Avoid in patients without airway support.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methocarbamol
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Methocarbamol with Sufentanil?
MediHelp rates the interaction as major. Methocarbamol and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sufentanil is a very potent opioid, and methocarbamol adds to sedation. The combination can cause profound sedation and respiratory depression, particularly in non-monitored settings.
How serious is the interaction between Methocarbamol and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only with continuous monitoring of sedation and respiratory status, and reduce doses as needed. Avoid in patients without airway support.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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