Drug interactions
Methocarbamol + Thioridazine
Severity: Moderate
Methocarbamol and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine is a sedating phenothiazine, and methocarbamol can add to drowsiness, dizziness and hypotension. Thioridazine also has significant QT-prolonging potential, but this is not changed by methocarbamol.
What this interaction means in plain words
Methocarbamol and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methocarbamol belongs to Musculoskeletal; Thioridazine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism.
What to do
Monitor for oversedation and orthostatic hypotension. Reduce the methocarbamol dose if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Methocarbamol with Thioridazine?
MediHelp rates the interaction as moderate. Methocarbamol and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine is a sedating phenothiazine, and methocarbamol can add to drowsiness, dizziness and hypotension. Thioridazine also has significant QT-prolonging potential, but this is not changed by methocarbamol.
How serious is the interaction between Methocarbamol and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic hypotension. Reduce the methocarbamol dose if excessive drowsiness occurs.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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