Drug interactions
Methohexital + Orphenadrin
Severity: Moderate
Methohexital and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic that causes marked CNS and respiratory depression. Orphenadrine adds sedative and anticholinergic effects, which can deepen sedation and delay recovery.
What this interaction means in plain words
Methohexital and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive CNS depression from pharmacodynamic synergy.
What to do
Tell the anesthesia team about orphenadrine use before the procedure. Titrate methohexital carefully and monitor sedation depth, ventilation and oxygenation through recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Orphenadrin?
MediHelp rates the interaction as moderate. Methohexital and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate anesthetic that causes marked CNS and respiratory depression. Orphenadrine adds sedative and anticholinergic effects, which can deepen sedation and delay recovery.
How serious is the interaction between Methohexital and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about orphenadrine use before the procedure. Titrate methohexital carefully and monitor sedation depth, ventilation and oxygenation through recovery.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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