Drug interactions
Methohexital + Probenecid
Severity: Minor
Methohexital and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid has been reported to prolong the effect of some anesthetic agents, but the interaction with methohexital is poorly documented. The mechanism is not established.
What this interaction means in plain words
Methohexital and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methohexital belongs to Central Nervous System; Probenecid belongs to Genitourinary.
Why it happens
Mechanism is not established; possible altered distribution or clearance of methohexital.
What to do
Titrate methohexital to effect and allow for possible prolonged recovery in patients taking probenecid.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Probenecid?
MediHelp rates the interaction as minor. Methohexital and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid has been reported to prolong the effect of some anesthetic agents, but the interaction with methohexital is poorly documented. The mechanism is not established.
How serious is the interaction between Methohexital and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital to effect and allow for possible prolonged recovery in patients taking probenecid.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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