Drug interactions
Methohexital + Quetiapine
Severity: Moderate
Methohexital and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic and combined with quetiapine increases CNS depression. This can lead to deep sedation, hypotension and respiratory depression.
What this interaction means in plain words
Methohexital and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and antipsychotic sedative effects.
What to do
Titrate methohexital carefully to effect with continuous monitoring of airway, ventilation and blood pressure. Use reduced doses if the patient has received quetiapine recently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Quetiapine?
MediHelp rates the interaction as moderate. Methohexital and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate anesthetic and combined with quetiapine increases CNS depression. This can lead to deep sedation, hypotension and respiratory depression.
How serious is the interaction between Methohexital and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully to effect with continuous monitoring of airway, ventilation and blood pressure. Use reduced doses if the patient has received quetiapine recently.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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