Drug interactions
Methohexital + Ziprasidone
Severity: Moderate
Methohexital and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic that causes marked CNS and respiratory depression, and ziprasidone adds sedation and may contribute to hypotension. The combination is relevant during procedural sedation or ECT anesthesia.
What this interaction means in plain words
Methohexital and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive hypotensive effects.
What to do
Titrate the anesthetic dose to effect with continuous monitoring of respiration and blood pressure. Ensure airway support is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Ziprasidone?
MediHelp rates the interaction as moderate. Methohexital and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic that causes marked CNS and respiratory depression, and ziprasidone adds sedation and may contribute to hypotension. The combination is relevant during procedural sedation or ECT anesthesia.
How serious is the interaction between Methohexital and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate the anesthetic dose to effect with continuous monitoring of respiration and blood pressure. Ensure airway support is available.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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