Drug interactions
Methotrexate + Ozanimod
Severity: Moderate
Methotrexate and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod lowers circulating lymphocytes, and adding methotrexate may further increase immunosuppression. Infection risk may persist for weeks after stopping either drug.
What this interaction means in plain words
Methotrexate and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Ozanimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression from S1P receptor-mediated lymphocyte sequestration and antimetabolite effects.
What to do
Monitor for infection and lymphocyte and total blood counts. Allow for the residual effects of prior immunosuppressants when switching therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Methotrexate with Ozanimod?
MediHelp rates the interaction as moderate. Methotrexate and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod lowers circulating lymphocytes, and adding methotrexate may further increase immunosuppression. Infection risk may persist for weeks after stopping either drug.
How serious is the interaction between Methotrexate and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and lymphocyte and total blood counts. Allow for the residual effects of prior immunosuppressants when switching therapy.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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