Drug interactions
Methotrexate + Paromomycin
Severity: Minor
Methotrexate and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin may lower absorption of oral methotrexate and disturb its enterohepatic recirculation. The result can be reduced methotrexate exposure and weaker effect.
What this interaction means in plain words
Methotrexate and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methotrexate belongs to Oncology; Paromomycin belongs to Anti Bacterial.
Why it happens
Aminoglycoside effects on gut mucosa and bowel flora may reduce methotrexate absorption.
What to do
Observe clinical response to oral methotrexate during paromomycin courses. Separate administration or use parenteral methotrexate if response is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Methotrexate with Paromomycin?
MediHelp rates the interaction as minor. Methotrexate and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin may lower absorption of oral methotrexate and disturb its enterohepatic recirculation. The result can be reduced methotrexate exposure and weaker effect.
How serious is the interaction between Methotrexate and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe clinical response to oral methotrexate during paromomycin courses. Separate administration or use parenteral methotrexate if response is lost.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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