Drug interactions
Methotrexate + Stiripentol
Severity: Moderate
Methotrexate and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-glycoprotein and BCRP, transporters involved in methotrexate disposition. Methotrexate exposure may rise, increasing the risk of myelosuppression, mucositis and hepatic or renal toxicity.
What this interaction means in plain words
Methotrexate and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits P-gp and BCRP efflux transporters, reducing methotrexate efflux and elimination.
What to do
Monitor blood counts, liver and renal function, and signs of methotrexate toxicity. Reduce the methotrexate dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Methotrexate with Stiripentol?
MediHelp rates the interaction as moderate. Methotrexate and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits P-glycoprotein and BCRP, transporters involved in methotrexate disposition. Methotrexate exposure may rise, increasing the risk of myelosuppression, mucositis and hepatic or renal toxicity.
How serious is the interaction between Methotrexate and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver and renal function, and signs of methotrexate toxicity. Reduce the methotrexate dose if adverse effects appear.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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