Drug interactions
Methotrexate + Vadadustat
Severity: Moderate
Methotrexate and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and OAT3, transporters involved in methotrexate elimination, and may raise methotrexate exposure. This can increase the risk of myelosuppression, mucositis and hepatic or renal toxicity.
What this interaction means in plain words
Methotrexate and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of BCRP and OAT3 transporters reduces the renal and biliary clearance of methotrexate.
What to do
Monitor blood counts, renal and liver function and signs of methotrexate toxicity. Reduce the methotrexate dose if toxicity appears, particularly with high-dose regimens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Methotrexate with Vadadustat?
MediHelp rates the interaction as moderate. Methotrexate and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits BCRP and OAT3, transporters involved in methotrexate elimination, and may raise methotrexate exposure. This can increase the risk of myelosuppression, mucositis and hepatic or renal toxicity.
How serious is the interaction between Methotrexate and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, renal and liver function and signs of methotrexate toxicity. Reduce the methotrexate dose if toxicity appears, particularly with high-dose regimens.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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