Drug interactions
Methoxsalen + Terbinafine
Severity: Minor
Methoxsalen and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxsalen is a potent CYP1A2 inhibitor and may raise terbinafine concentrations. Because terbinafine is cleared by several enzymes, the increase is probably modest.
What this interaction means in plain words
Methoxsalen and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methoxsalen belongs to Anti Fungals; Terbinafine belongs to Anti Fungals.
Why it happens
Methoxsalen inhibits CYP1A2, reducing one of the pathways of terbinafine clearance.
What to do
No dose adjustment is usually needed; monitor for terbinafine adverse effects such as gastrointestinal symptoms and liver enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methoxsalen and Terbinafine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Terbinafine?
MediHelp rates the interaction as minor. Methoxsalen and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methoxsalen is a potent CYP1A2 inhibitor and may raise terbinafine concentrations. Because terbinafine is cleared by several enzymes, the increase is probably modest.
How serious is the interaction between Methoxsalen and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for terbinafine adverse effects such as gastrointestinal symptoms and liver enzyme elevation.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
