Drug interactions
Methscopolamine + Trazodone
Severity: Minor
Methscopolamine and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has some weak anticholinergic activity, and methscopolamine is a peripherally acting antimuscarinic. Taken together they may add to dry mouth, constipation, urinary retention and blurred vision, particularly in older patients. The effect is usually modest.
What this interaction means in plain words
Methscopolamine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antimuscarinic effects, with trazodone contributing only weak anticholinergic activity.
What to do
Ask patients about dry mouth, constipation and urinary hesitancy, and reduce or stop methscopolamine if these become troublesome. Take extra care in elderly patients and in those with glaucoma or prostatic hypertrophy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Methscopolamine with Trazodone?
MediHelp rates the interaction as minor. Methscopolamine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trazodone has some weak anticholinergic activity, and methscopolamine is a peripherally acting antimuscarinic. Taken together they may add to dry mouth, constipation, urinary retention and blurred vision, particularly in older patients. The effect is usually modest.
How serious is the interaction between Methscopolamine and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about dry mouth, constipation and urinary hesitancy, and reduce or stop methscopolamine if these become troublesome. Take extra care in elderly patients and in those with glaucoma or prostatic hypertrophy.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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