Drug interactions
Methsuximide + Orlistat
Severity: Moderate
Methsuximide and Orlistat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat has been reported to lower antiepileptic concentrations and precipitate seizures. Evidence for methsuximide specifically is absent.
What this interaction means in plain words
Methsuximide and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methsuximide belongs to Central Nervous System; Orlistat belongs to Miscellaneous.
Why it happens
Possible decreased gastrointestinal absorption from fat malabsorption; not established for methsuximide.
What to do
Monitor seizure control when orlistat is started or stopped, and measure the active metabolite level if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orlistat
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
- Cholecalciferol + Orlistat Moderate
Other interactions of Methsuximide
- Amisulpride + Methsuximide Moderate
- Amobarbital + Methsuximide Moderate
- Apalutamide + Methsuximide Moderate
- Asenapine + Methsuximide Moderate
- Brexpiprazole + Methsuximide Moderate
- Brivaracetam + Methsuximide Moderate
Frequently asked questions
Can I take Methsuximide with Orlistat?
MediHelp rates the interaction as moderate. Methsuximide and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat has been reported to lower antiepileptic concentrations and precipitate seizures. Evidence for methsuximide specifically is absent.
How serious is the interaction between Methsuximide and Orlistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control when orlistat is started or stopped, and measure the active metabolite level if control worsens.
What other medicines interact with Orlistat?
MediHelp also lists interactions of Orlistat with, for example, Cyclosporin, Triheptanoin, Amiodarone. The full list is on the Orlistat page.
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