Drug interactions
Methyclothiazide + Midodrine
Severity: Minor
Methyclothiazide and Midodrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine's active metabolite is secreted by renal tubular cation transport, and a thiazide could theoretically compete for it. Any rise in midodrine effect is expected to be small. Thiazide-induced volume loss may also lower blood pressure, partly opposing midodrine's effect.
What this interaction means in plain words
Methyclothiazide and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical competition for renal tubular secretion of the active metabolite desglymidodrine, plus pharmacodynamic opposition.
What to do
Monitor supine and standing blood pressure when starting or changing the thiazide. Adjust midodrine dose to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Methyclothiazide with Midodrine?
MediHelp rates the interaction as minor. Methyclothiazide and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midodrine's active metabolite is secreted by renal tubular cation transport, and a thiazide could theoretically compete for it. Any rise in midodrine effect is expected to be small. Thiazide-induced volume loss may also lower blood pressure, partly opposing midodrine's effect.
How serious is the interaction between Methyclothiazide and Midodrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when starting or changing the thiazide. Adjust midodrine dose to response.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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