Drug interactions
Methyclothiazide + Vitamin d
Severity: Moderate
Methyclothiazide and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion, and with vitamin D this can cause hypercalcemia. The risk is higher with high-dose vitamin D, calcium supplements or reduced kidney function.
What this interaction means in plain words
Methyclothiazide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides increase renal calcium reabsorption while vitamin D increases intestinal calcium absorption, so serum calcium rises additively.
What to do
Check serum calcium at baseline and periodically during combined therapy. Lower the vitamin D or calcium dose, or change the diuretic, if calcium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vitamin d
Frequently asked questions
Can I take Methyclothiazide with Vitamin d?
MediHelp rates the interaction as moderate. Methyclothiazide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, and with vitamin D this can cause hypercalcemia. The risk is higher with high-dose vitamin D, calcium supplements or reduced kidney function.
How serious is the interaction between Methyclothiazide and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium at baseline and periodically during combined therapy. Lower the vitamin D or calcium dose, or change the diuretic, if calcium rises.
What other medicines interact with Vitamin d?
MediHelp also lists interactions of Vitamin d with, for example, Aluminum hydroxide, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Vitamin d page.
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