Drug interactions
Methyldopa + Midazolam
Severity: Moderate
Methyldopa and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methyldopa commonly causes sedation and drowsiness, particularly at treatment start, and this may add to the effects of midazolam. Hypotension from either drug may also be additive.
What this interaction means in plain words
Methyldopa and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methyldopa belongs to Cardiovascular; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects; methyldopa acts via central alpha-2 agonism through its metabolite.
What to do
Use a reduced midazolam dose and monitor sedation and blood pressure, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Methyldopa
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
Frequently asked questions
Can I take Methyldopa with Midazolam?
MediHelp rates the interaction as moderate. Methyldopa and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methyldopa commonly causes sedation and drowsiness, particularly at treatment start, and this may add to the effects of midazolam. Hypotension from either drug may also be additive.
How serious is the interaction between Methyldopa and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced midazolam dose and monitor sedation and blood pressure, especially in older patients.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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