Drug interactions
Methylene blue + Tedizolid
Severity: Major
Methylene blue and Tedizolid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylene blue is a potent MAO-A inhibitor associated with serotonin syndrome with serotonergic drugs. Tedizolid is a weaker MAO inhibitor, but the combination may still add serotonergic risk.
What this interaction means in plain words
Methylene blue and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive MAO inhibition, with methylene blue as the dominant contributor.
What to do
Avoid if possible and use an alternative antibiotic when methylene blue is needed. If both are required, monitor closely for serotonin syndrome.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Methylene blue with Tedizolid?
MediHelp rates the interaction as major. Methylene blue and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methylene blue is a potent MAO-A inhibitor associated with serotonin syndrome with serotonergic drugs. Tedizolid is a weaker MAO inhibitor, but the combination may still add serotonergic risk.
How serious is the interaction between Methylene blue and Tedizolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use an alternative antibiotic when methylene blue is needed. If both are required, monitor closely for serotonin syndrome.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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