Drug interactions
Methylenedioxymethamphetamine + Oxycodone
Severity: Moderate
Methylenedioxymethamphetamine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a serotonergic stimulant and oxycodone has weak serotonergic activity, so serotonin toxicity is a theoretical concern. MDMA stimulant effects may also mask opioid sedation, so the patient can become suddenly overly sedated as MDMA wears off.
What this interaction means in plain words
Methylenedioxymethamphetamine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS effects with possible additive serotonergic activity; MDMA also inhibits CYP2D6.
What to do
Counsel against recreational MDMA use with opioids and monitor for agitation, hyperthermia, clonus or respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Methylenedioxymethamphetamine with Oxycodone?
MediHelp rates the interaction as moderate. Methylenedioxymethamphetamine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is a serotonergic stimulant and oxycodone has weak serotonergic activity, so serotonin toxicity is a theoretical concern. MDMA stimulant effects may also mask opioid sedation, so the patient can become suddenly overly sedated as MDMA wears off.
How serious is the interaction between Methylenedioxymethamphetamine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel against recreational MDMA use with opioids and monitor for agitation, hyperthermia, clonus or respiratory depression.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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