Drug interactions
Methylenedioxymethamphetamine + Risperidone
Severity: Moderate
Methylenedioxymethamphetamine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is an illicit serotonergic stimulant that can cause hyperthermia, tachycardia and hypertension, and it is partly metabolized by CYP2D6. Risperidone blocks serotonin and dopamine receptors and may modify its effects, but the interaction is unpredictable and can include dangerous hyperthermia or arrhythmia.
What this interaction means in plain words
Methylenedioxymethamphetamine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing and overlapping serotonergic and dopaminergic actions, with possible CYP2D6 competition.
What to do
Counsel patients against MDMA use. If exposure occurs, monitor temperature, heart rate, blood pressure and mental status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methylenedioxymethamphetamine and Risperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Methylenedioxymethamphetamine with Risperidone?
MediHelp rates the interaction as moderate. Methylenedioxymethamphetamine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is an illicit serotonergic stimulant that can cause hyperthermia, tachycardia and hypertension, and it is partly metabolized by CYP2D6. Risperidone blocks serotonin and dopamine receptors and may modify its effects, but the interaction is unpredictable and can include dangerous hyperthermia or arrhythmia.
How serious is the interaction between Methylenedioxymethamphetamine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients against MDMA use. If exposure occurs, monitor temperature, heart rate, blood pressure and mental status.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
