Drug interactions
Methylergonovine + Midodrine
Severity: Major
Methylergonovine and Midodrine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine causes strong uterine and vascular smooth muscle contraction and can raise blood pressure. With midodrine, additive vasoconstriction may cause severe hypertension or vasospasm.
What this interaction means in plain words
Methylergonovine and Midodrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive vasoconstriction from ergot-mediated and alpha-1 adrenergic agonist effects.
What to do
Avoid concurrent use where possible and hold midodrine if methylergonovine is needed. If combined, monitor blood pressure closely and for ischemic symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Methylergonovine with Midodrine?
MediHelp rates the interaction as major. Methylergonovine and Midodrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methylergonovine causes strong uterine and vascular smooth muscle contraction and can raise blood pressure. With midodrine, additive vasoconstriction may cause severe hypertension or vasospasm.
How serious is the interaction between Methylergonovine and Midodrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and hold midodrine if methylergonovine is needed. If combined, monitor blood pressure closely and for ischemic symptoms.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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