Drug interactions
Methylergonovine + Rizatriptan
Severity: Contraindicated
Methylergonovine and Rizatriptan: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine is a strong ergot vasoconstrictor, and rizatriptan adds to this effect. Prolonged vasospasm with ischemia of the heart, brain or limbs may occur.
What this interaction means in plain words
Methylergonovine and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive vasoconstriction through 5-HT1B/1D agonism and ergot adrenergic and serotonergic effects.
What to do
Avoid use together and separate by at least 24 hours. Use a non-ergot uterotonic such as oxytocin when bleeding must be controlled.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Methylergonovine with Rizatriptan?
MediHelp rates the interaction as contraindicated. Methylergonovine and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylergonovine is a strong ergot vasoconstrictor, and rizatriptan adds to this effect. Prolonged vasospasm with ischemia of the heart, brain or limbs may occur.
How serious is the interaction between Methylergonovine and Rizatriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use together and separate by at least 24 hours. Use a non-ergot uterotonic such as oxytocin when bleeding must be controlled.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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