Drug interactions
Methylphenidate + Sacubitril-valsartan
Severity: Minor
Methylphenidate and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylphenidate has sympathomimetic effects and can raise blood pressure and heart rate. This may partly counteract the antihypertensive effect of sacubitril-valsartan.
What this interaction means in plain words
Methylphenidate and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methylphenidate belongs to Central Nervous System; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism through sympathomimetic pressor effects of methylphenidate.
What to do
Monitor blood pressure after starting or changing methylphenidate and adjust antihypertensive therapy if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Methylphenidate
- Isocarboxazid + Methylphenidate Contraindicated
- Linezolid + Methylphenidate Contraindicated
- Methylphenidate + Phenelzine Contraindicated
- Methylphenidate + Procarbazine Contraindicated
- Methylphenidate + Rasagiline Contraindicated
- Methylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Methylphenidate with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Methylphenidate and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methylphenidate has sympathomimetic effects and can raise blood pressure and heart rate. This may partly counteract the antihypertensive effect of sacubitril-valsartan.
How serious is the interaction between Methylphenidate and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or changing methylphenidate and adjust antihypertensive therapy if control is lost.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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