Drug interactions
Methylprednisolone + Metronidazole
Severity: Minor
Methylprednisolone and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole has been reported to reduce corticosteroid clearance in some cases, but any rise in methylprednisolone exposure is probably small. Clinical consequences are unlikely in most patients.
What this interaction means in plain words
Methylprednisolone and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methylprednisolone belongs to Endocrine; Metronidazole belongs to Anti Parasitic.
Why it happens
Possible weak inhibition of corticosteroid metabolism by metronidazole; the mechanism is not well established.
What to do
No dose adjustment is normally needed. Watch for steroid adverse effects such as hyperglycemia and fluid retention during extended co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Methylprednisolone with Metronidazole?
MediHelp rates the interaction as minor. Methylprednisolone and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole has been reported to reduce corticosteroid clearance in some cases, but any rise in methylprednisolone exposure is probably small. Clinical consequences are unlikely in most patients.
How serious is the interaction between Methylprednisolone and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is normally needed. Watch for steroid adverse effects such as hyperglycemia and fluid retention during extended co-therapy.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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