Drug interactions
Methylprednisolone + Miconazole vaginal
Severity: Minor
Methylprednisolone and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole is a CYP3A4 inhibitor, but vaginal use gives low systemic exposure. A clinically relevant rise in methylprednisolone levels is unlikely except with repeated or prolonged use.
What this interaction means in plain words
Methylprednisolone and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Systemically absorbed miconazole may inhibit CYP3A4 metabolism of methylprednisolone, but absorption is limited.
What to do
No action usually needed; watch for steroid excess if used long term or at high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Methylprednisolone with Miconazole vaginal?
MediHelp rates the interaction as minor. Methylprednisolone and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Miconazole is a CYP3A4 inhibitor, but vaginal use gives low systemic exposure. A clinically relevant rise in methylprednisolone levels is unlikely except with repeated or prolonged use.
How serious is the interaction between Methylprednisolone and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action usually needed; watch for steroid excess if used long term or at high doses.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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