Drug interactions
Methylprednisolone + Midazolam intranasal
Severity: Minor
Methylprednisolone and Midazolam intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylprednisolone is a weak CYP3A4 inhibitor and may slightly raise midazolam concentrations. This could prolong sedation, though the effect is expected to be small.
What this interaction means in plain words
Methylprednisolone and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP3A4 by methylprednisolone reducing midazolam clearance.
What to do
No dose change is generally needed; observe for prolonged sedation and respiratory depression after dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Methylprednisolone with Midazolam intranasal?
MediHelp rates the interaction as minor. Methylprednisolone and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methylprednisolone is a weak CYP3A4 inhibitor and may slightly raise midazolam concentrations. This could prolong sedation, though the effect is expected to be small.
How serious is the interaction between Methylprednisolone and Midazolam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; observe for prolonged sedation and respiratory depression after dosing.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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