Drug interactions
Methylprednisolone + Parecoxib
Severity: Moderate
Methylprednisolone and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use of a corticosteroid and an NSAID raises the risk of gastrointestinal ulceration and bleeding. Parecoxib is COX-2 selective, which lowers but does not eliminate this risk when given with steroids.
What this interaction means in plain words
Methylprednisolone and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury from impaired prostaglandin protection and corticosteroid effects on mucosal healing.
What to do
Use the lowest effective doses for the shortest duration and consider gastroprotection with a proton pump inhibitor in higher-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Methylprednisolone with Parecoxib?
MediHelp rates the interaction as moderate. Methylprednisolone and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use of a corticosteroid and an NSAID raises the risk of gastrointestinal ulceration and bleeding. Parecoxib is COX-2 selective, which lowers but does not eliminate this risk when given with steroids.
How serious is the interaction between Methylprednisolone and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and consider gastroprotection with a proton pump inhibitor in higher-risk patients.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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