Drug interactions
Methylprednisolone + Phenindione
Severity: Moderate
Methylprednisolone and Phenindione: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can alter the anticoagulant response to vitamin K antagonists, in either direction, and may increase bleeding through gastric and vascular effects. INR can become unpredictable, particularly with high-dose or changing steroid therapy.
What this interaction means in plain words
Methylprednisolone and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mixed pharmacodynamic effects on coagulation and mucosal or vascular integrity; the pharmacokinetic mechanism is not well defined.
What to do
Monitor INR more frequently when starting, changing or stopping methylprednisolone and adjust phenindione dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Methylprednisolone with Phenindione?
MediHelp rates the interaction as moderate. Methylprednisolone and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can alter the anticoagulant response to vitamin K antagonists, in either direction, and may increase bleeding through gastric and vascular effects. INR can become unpredictable, particularly with high-dose or changing steroid therapy.
How serious is the interaction between Methylprednisolone and Phenindione?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently when starting, changing or stopping methylprednisolone and adjust phenindione dose accordingly.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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