Drug interactions
Methylprednisolone + Squill
Severity: Moderate
Methylprednisolone and Squill: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Squill contains cardiac glycosides. Corticosteroids can cause hypokalemia through mineralocorticoid effects, which increases sensitivity to glycoside toxicity and the risk of arrhythmias.
What this interaction means in plain words
Methylprednisolone and Squill can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid-induced potassium loss increases myocardial sensitivity to cardiac glycosides.
What to do
Monitor serum potassium and magnesium and correct deficits; watch for signs of glycoside toxicity or arrhythmia. Avoid squill where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Methylprednisolone with Squill?
MediHelp rates the interaction as moderate. Methylprednisolone and Squill can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Squill contains cardiac glycosides. Corticosteroids can cause hypokalemia through mineralocorticoid effects, which increases sensitivity to glycoside toxicity and the risk of arrhythmias.
How serious is the interaction between Methylprednisolone and Squill?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficits; watch for signs of glycoside toxicity or arrhythmia. Avoid squill where possible.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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