Drug interactions
methylprednisolone + terbutaline
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive hypokalemia and potential arrhythmias when systemic corticosteroids are used with beta-2 agonists.
Mechanism of action
Beta-2 agonist drives intracellular K+ shift; corticosteroids have mineralocorticoid effects → increased renal K+ loss.
Clinical management
Monitor serum potassium (baseline and periodically), ECG if high doses or cardiac disease; consider K+ supplementation; use lowest effective doses.
Drug reference
References
- Terbutaline Sulfate Injection Prescribing Information — Warnings/Precautions (hypokalemia, interactions) — FDA Label
- Terbutaline — Drug Interactions — Lexicomp
- Systemic glucocorticoids: Side effects and dosing — electrolyte disturbances — UpToDate
Frequently asked questions
Can I take methylprednisolone with terbutaline?
The interaction is rated: Moderate. Additive hypokalemia and potential arrhythmias when systemic corticosteroids are used with beta-2 agonists.
How serious is the interaction between methylprednisolone and terbutaline?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between methylprednisolone and terbutaline managed?
Monitor serum potassium (baseline and periodically), ECG if high doses or cardiac disease; consider K+ supplementation; use lowest effective doses.
Why do methylprednisolone and terbutaline interact?
Beta-2 agonist drives intracellular K+ shift; corticosteroids have mineralocorticoid effects → increased renal K+ loss.
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