Drug interactions
Methylprednisolone + Typhoid vaccine live
Severity: Major
Methylprednisolone and Typhoid vaccine live: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live attenuated oral typhoid vaccine may cause disseminated infection in patients with corticosteroid-induced immunosuppression, and the vaccine response may also be reduced. The risk depends on steroid dose and duration, and is greatest with high-dose or prolonged therapy.
What this interaction means in plain words
Methylprednisolone and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Corticosteroid immunosuppression impairs control of the replicating attenuated organism and reduces vaccine immunogenicity.
What to do
Avoid live typhoid vaccine in patients on immunosuppressive steroid doses; use the inactivated polysaccharide vaccine instead. Wait about one month after stopping high-dose steroids before live vaccination.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Methylprednisolone with Typhoid vaccine live?
MediHelp rates the interaction as major. Methylprednisolone and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Live attenuated oral typhoid vaccine may cause disseminated infection in patients with corticosteroid-induced immunosuppression, and the vaccine response may also be reduced. The risk depends on steroid dose and duration, and is greatest with high-dose or prolonged therapy.
How serious is the interaction between Methylprednisolone and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live typhoid vaccine in patients on immunosuppressive steroid doses; use the inactivated polysaccharide vaccine instead. Wait about one month after stopping high-dose steroids before live vaccination.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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