Drug interactions
Metipranolol + Sotalol
Severity: Moderate
Metipranolol and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ophthalmic metipranolol is a non-selective beta-blocker with some systemic absorption. With sotalol it may produce additive bradycardia and hypotension.
What this interaction means in plain words
Metipranolol and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic blockade.
What to do
Monitor heart rate and blood pressure; consider a non-beta-blocker glaucoma agent in patients with bradycardia or conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Metipranolol with Sotalol?
MediHelp rates the interaction as moderate. Metipranolol and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ophthalmic metipranolol is a non-selective beta-blocker with some systemic absorption. With sotalol it may produce additive bradycardia and hypotension.
How serious is the interaction between Metipranolol and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure; consider a non-beta-blocker glaucoma agent in patients with bradycardia or conduction disease.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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