Drug interactions
Metoclopramide intranasal + Oxycodone
Severity: Moderate
Metoclopramide intranasal and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastric emptying and antagonize the prokinetic action of metoclopramide, reducing its effect in gastroparesis. Metoclopramide also adds to central nervous system effects such as drowsiness and dizziness.
What this interaction means in plain words
Metoclopramide intranasal and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing effects on gastrointestinal motility (opioid mu-receptor agonism versus dopamine antagonism and cholinergic prokinetic action), plus additive CNS effects.
What to do
Monitor for reduced gastric motility benefit and for sedation or dizziness. Consider minimizing opioid dose or an alternative for gastroparesis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Metoclopramide intranasal with Oxycodone?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastric emptying and antagonize the prokinetic action of metoclopramide, reducing its effect in gastroparesis. Metoclopramide also adds to central nervous system effects such as drowsiness and dizziness.
How serious is the interaction between Metoclopramide intranasal and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced gastric motility benefit and for sedation or dizziness. Consider minimizing opioid dose or an alternative for gastroparesis symptoms.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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