Drug interactions
Metoclopramide intranasal + Pregabalin
Severity: Moderate
Metoclopramide intranasal and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause drowsiness, dizziness and, less commonly, extrapyramidal or other central nervous system effects, which may be additive with pregabalin sedation. The combination may reduce alertness and impair coordination.
What this interaction means in plain words
Metoclopramide intranasal and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system effects; metoclopramide's central dopamine antagonism combines with pregabalin's sedative effect.
What to do
Counsel on drowsiness and avoid driving until response is known. Monitor for sedation and movement disorders, and reduce doses if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metoclopramide intranasal and Pregabalin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pregabalin
Frequently asked questions
Can I take Metoclopramide intranasal with Pregabalin?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause drowsiness, dizziness and, less commonly, extrapyramidal or other central nervous system effects, which may be additive with pregabalin sedation. The combination may reduce alertness and impair coordination.
How serious is the interaction between Metoclopramide intranasal and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoid driving until response is known. Monitor for sedation and movement disorders, and reduce doses if adverse effects occur.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
