Drug interactions
Metoclopramide intranasal + Sevoflurane
Severity: Moderate
Metoclopramide intranasal and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide has central dopamine-blocking and sedative effects and can reduce anesthetic requirements. Combined with sevoflurane, it may add to sedation and cause extrapyramidal reactions or hemodynamic effects in the perioperative period. The clinical significance is generally modest.
What this interaction means in plain words
Metoclopramide intranasal and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression, with dopamine D2 antagonism from metoclopramide.
What to do
Avoid intranasal metoclopramide shortly before or during anesthesia unless needed, and use another antiemetic if appropriate. Monitor sedation level and watch for extrapyramidal symptoms postoperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metoclopramide intranasal and Sevoflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sevoflurane
Frequently asked questions
Can I take Metoclopramide intranasal with Sevoflurane?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide has central dopamine-blocking and sedative effects and can reduce anesthetic requirements. Combined with sevoflurane, it may add to sedation and cause extrapyramidal reactions or hemodynamic effects in the perioperative period. The clinical significance is generally modest.
How serious is the interaction between Metoclopramide intranasal and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid intranasal metoclopramide shortly before or during anesthesia unless needed, and use another antiemetic if appropriate. Monitor sedation level and watch for extrapyramidal symptoms postoperatively.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
