Drug interactions
Metoclopramide intranasal + Trimipramine
Severity: Moderate
Metoclopramide intranasal and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide is a dopamine antagonist that can cause extrapyramidal reactions, and combined use with tricyclics may increase CNS adverse effects and QT risk. Trimipramine inhibits CYP2D6 weakly and may modestly alter metoclopramide exposure.
What this interaction means in plain words
Metoclopramide intranasal and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS dopaminergic and anticholinergic effects, with possible CYP2D6-related changes in metoclopramide levels.
What to do
Monitor for extrapyramidal symptoms, sedation and arrhythmia. Consider an alternative antiemetic or prokinetic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Metoclopramide intranasal with Trimipramine?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide is a dopamine antagonist that can cause extrapyramidal reactions, and combined use with tricyclics may increase CNS adverse effects and QT risk. Trimipramine inhibits CYP2D6 weakly and may modestly alter metoclopramide exposure.
How serious is the interaction between Metoclopramide intranasal and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and arrhythmia. Consider an alternative antiemetic or prokinetic if symptoms develop.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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