Drug interactions
Metoclopramide intranasal + Vigabatrin
Severity: Moderate
Metoclopramide intranasal and Vigabatrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause CNS effects such as drowsiness, extrapyramidal symptoms and depression, and vigabatrin also has CNS and psychiatric adverse effects. The clinical significance is unclear and probably modest. The combination may worsen sedation or mood effects.
What this interaction means in plain words
Metoclopramide intranasal and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive CNS adverse effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for sedation, mood changes and movement disorders when both drugs are used. Consider an alternative antiemetic or prokinetic if CNS effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Asenapine + Vigabatrin Moderate
- Avapritinib + Vigabatrin Moderate
- Benzhydrocodone / acetaminophen + Vigabatrin Moderate
- Brexanolone + Vigabatrin Moderate
Frequently asked questions
Can I take Metoclopramide intranasal with Vigabatrin?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause CNS effects such as drowsiness, extrapyramidal symptoms and depression, and vigabatrin also has CNS and psychiatric adverse effects. The clinical significance is unclear and probably modest. The combination may worsen sedation or mood effects.
How serious is the interaction between Metoclopramide intranasal and Vigabatrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, mood changes and movement disorders when both drugs are used. Consider an alternative antiemetic or prokinetic if CNS effects develop.
What other medicines interact with Vigabatrin?
MediHelp also lists interactions of Vigabatrin with, for example, Amisulpride, Asenapine transdermal, Asenapine. The full list is on the Vigabatrin page.
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