Drug interactions
Metolazone + Mycophenolate
Severity: Minor
Metolazone and Mycophenolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone may compete with mycophenolic acid glucuronide for renal tubular secretion, potentially raising exposure to the metabolite. The clinical importance is uncertain and based largely on mechanistic reasoning.
What this interaction means in plain words
Metolazone and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular anionic transport reduces clearance of mycophenolate metabolites.
What to do
No empiric dose change is needed. Monitor for mycophenolate adverse effects such as cytopenias and gastrointestinal toxicity, particularly in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Mycophenolate?
MediHelp rates the interaction as minor. Metolazone and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metolazone may compete with mycophenolic acid glucuronide for renal tubular secretion, potentially raising exposure to the metabolite. The clinical importance is uncertain and based largely on mechanistic reasoning.
How serious is the interaction between Metolazone and Mycophenolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for mycophenolate adverse effects such as cytopenias and gastrointestinal toxicity, particularly in renal impairment.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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