Drug interactions
Metolazone + Olmesartan
Severity: Moderate
Metolazone and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone adds to the blood pressure lowering of olmesartan and may cause hypotension and volume depletion, with a risk of renal function changes. Olmesartan partly counteracts thiazide-induced potassium loss.
What this interaction means in plain words
Metolazone and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metolazone belongs to Cardiovascular; Olmesartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect via diuresis and angiotensin receptor blockade, with opposing effects on potassium.
What to do
Monitor blood pressure, potassium, sodium and creatinine after initiation or dose changes. Reduce the diuretic dose if symptomatic hypotension or volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Metolazone with Olmesartan?
MediHelp rates the interaction as moderate. Metolazone and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone adds to the blood pressure lowering of olmesartan and may cause hypotension and volume depletion, with a risk of renal function changes. Olmesartan partly counteracts thiazide-induced potassium loss.
How serious is the interaction between Metolazone and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium, sodium and creatinine after initiation or dose changes. Reduce the diuretic dose if symptomatic hypotension or volume depletion occurs.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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