Drug interactions
Metolazone + Olodaterol inhaled
Severity: Moderate
Metolazone and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may lower serum potassium, so combined use can lead to hypokalemia and increased arrhythmia risk. The risk is greater in patients with cardiac disease, hypoxia or other potassium-lowering drugs.
What this interaction means in plain words
Metolazone and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Renal potassium loss from metolazone plus beta-2 agonist-induced cellular potassium uptake.
What to do
Monitor serum potassium and magnesium periodically and replace deficits. Ensure olodaterol is not used above the labeled dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Metolazone and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may lower serum potassium, so combined use can lead to hypokalemia and increased arrhythmia risk. The risk is greater in patients with cardiac disease, hypoxia or other potassium-lowering drugs.
How serious is the interaction between Metolazone and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically and replace deficits. Ensure olodaterol is not used above the labeled dose.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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