Drug interactions
Metolazone + Pindolol
Severity: Minor
Metolazone and Pindolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together these drugs provide additive blood pressure lowering, which can cause hypotension or bradycardia in sensitive patients. Metolazone may also cause hypokalemia and hyperglycemia, which beta-blocker therapy can complicate.
What this interaction means in plain words
Metolazone and Pindolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antihypertensive effect from diuresis and beta-adrenergic blockade.
What to do
Monitor blood pressure, heart rate, serum potassium and glucose. Reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Pindolol?
MediHelp rates the interaction as minor. Metolazone and Pindolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Together these drugs provide additive blood pressure lowering, which can cause hypotension or bradycardia in sensitive patients. Metolazone may also cause hypokalemia and hyperglycemia, which beta-blocker therapy can complicate.
How serious is the interaction between Metolazone and Pindolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, serum potassium and glucose. Reduce doses if symptomatic hypotension occurs.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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