Drug interactions
Metolazone + Shark cartilage
Severity: Minor
Metolazone and Shark cartilage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shark cartilage supplements contain calcium and have been associated with hypercalcemia, and thiazide-type diuretics reduce urinary calcium excretion. Together they could theoretically raise serum calcium.
What this interaction means in plain words
Metolazone and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-type reduction in renal calcium excretion combined with calcium load from the supplement.
What to do
Advise avoiding shark cartilage supplements. If used, monitor serum calcium.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Shark cartilage?
MediHelp rates the interaction as minor. Metolazone and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Shark cartilage supplements contain calcium and have been associated with hypercalcemia, and thiazide-type diuretics reduce urinary calcium excretion. Together they could theoretically raise serum calcium.
How serious is the interaction between Metolazone and Shark cartilage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding shark cartilage supplements. If used, monitor serum calcium.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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