Drug interactions
Metolazone + Telmisartan-amlodipine
Severity: Moderate
Metolazone and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone adds strongly to the diuretic and antihypertensive effects of the combination and can cause marked sodium and potassium loss, volume depletion, hypotension and renal impairment. Effects can be pronounced when metolazone is added to another thiazide, and potassium may be affected in either direction.
What this interaction means in plain words
Metolazone and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metolazone belongs to Cardiovascular; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Additive sodium and water depletion through sequential nephron blockade together with angiotensin receptor blockade, with additive potassium wasting.
What to do
Monitor electrolytes, creatinine, weight and blood pressure closely after starting. Start metolazone at a low dose and avoid duplicate thiazide therapy where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Metolazone and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone adds strongly to the diuretic and antihypertensive effects of the combination and can cause marked sodium and potassium loss, volume depletion, hypotension and renal impairment. Effects can be pronounced when metolazone is added to another thiazide, and potassium may be affected in either direction.
How serious is the interaction between Metolazone and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, creatinine, weight and blood pressure closely after starting. Start metolazone at a low dose and avoid duplicate thiazide therapy where possible.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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