Drug interactions
Metolazone + Telmisartan
Severity: Moderate
Metolazone and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone adds to the blood pressure lowering of telmisartan and may cause hypotension or volume depletion. Telmisartan tends to counter thiazide-induced hypokalemia, and renal function may change.
What this interaction means in plain words
Metolazone and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metolazone belongs to Cardiovascular; Telmisartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect from diuresis and angiotensin receptor blockade, with opposing potassium effects.
What to do
Monitor blood pressure, potassium, sodium and creatinine after starting or changing doses. Lower the diuretic dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Metolazone with Telmisartan?
MediHelp rates the interaction as moderate. Metolazone and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone adds to the blood pressure lowering of telmisartan and may cause hypotension or volume depletion. Telmisartan tends to counter thiazide-induced hypokalemia, and renal function may change.
How serious is the interaction between Metolazone and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium, sodium and creatinine after starting or changing doses. Lower the diuretic dose if hypotension occurs.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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