Drug interactions
Metolazone + Temocillin
Severity: Minor
Metolazone and Temocillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both metolazone and temocillin are eliminated by the kidney, and thiazide-type diuretics may reduce tubular handling of penicillins. Temocillin exposure could rise, and metolazone-related volume depletion could further reduce renal clearance. Clinical consequences are likely modest.
What this interaction means in plain words
Metolazone and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion and diuretic-induced volume depletion reducing renal clearance; not well characterized.
What to do
Monitor renal function and electrolytes during combined therapy, particularly in elderly or renally impaired patients. Adjust temocillin dose to creatinine clearance if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metolazone and Temocillin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Temocillin?
MediHelp rates the interaction as minor. Metolazone and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both metolazone and temocillin are eliminated by the kidney, and thiazide-type diuretics may reduce tubular handling of penicillins. Temocillin exposure could rise, and metolazone-related volume depletion could further reduce renal clearance. Clinical consequences are likely modest.
How serious is the interaction between Metolazone and Temocillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and electrolytes during combined therapy, particularly in elderly or renally impaired patients. Adjust temocillin dose to creatinine clearance if renal function declines.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
