Drug interactions
Metolazone + Ticarcillin
Severity: Moderate
Metolazone and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticarcillin is given as a sodium salt with a high sodium load and can lower serum potassium, which may add to the potassium wasting caused by metolazone. Hypokalemia can become significant in patients on high-dose ticarcillin. Both drugs are also renally cleared.
What this interaction means in plain words
Metolazone and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium loss through diuretic-induced kaliuresis and ticarcillin's nonreabsorbable anion and sodium load increasing distal potassium excretion.
What to do
Monitor serum potassium and magnesium regularly and replace as needed. Adjust ticarcillin dose for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Ticarcillin?
MediHelp rates the interaction as moderate. Metolazone and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticarcillin is given as a sodium salt with a high sodium load and can lower serum potassium, which may add to the potassium wasting caused by metolazone. Hypokalemia can become significant in patients on high-dose ticarcillin. Both drugs are also renally cleared.
How serious is the interaction between Metolazone and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace as needed. Adjust ticarcillin dose for renal function.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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