Drug interactions
Metoprolol + Nifedipine
Severity: Minor
Metoprolol and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine and metoprolol are often used together, and the combination lowers blood pressure more than either alone. Occasionally excessive hypotension occurs, and rarely heart failure worsens in patients with poor ventricular function.
What this interaction means in plain words
Metoprolol and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metoprolol belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from vasodilation (calcium channel blockade) and beta-1 blockade.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug. Use the lowest effective doses in patients with left ventricular dysfunction.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Nifedipine
Frequently asked questions
Can I take Metoprolol with Nifedipine?
MediHelp rates the interaction as minor. Metoprolol and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine and metoprolol are often used together, and the combination lowers blood pressure more than either alone. Occasionally excessive hypotension occurs, and rarely heart failure worsens in patients with poor ventricular function.
How serious is the interaction between Metoprolol and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug. Use the lowest effective doses in patients with left ventricular dysfunction.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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