Drug interactions
Metoprolol + Oxazepam
Severity: Minor
Metoprolol and Oxazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxazepam is cleared by glucuronidation rather than oxidative metabolism, so a meaningful pharmacokinetic interaction with metoprolol is not expected. No clinically important effect has been established.
What this interaction means in plain words
Metoprolol and Oxazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metoprolol belongs to Cardiovascular; Oxazepam belongs to Central Nervous System.
Why it happens
No established mechanism; oxazepam is glucuronidated and not dependent on CYP pathways affected by metoprolol.
What to do
No specific action is needed beyond usual monitoring of sedation and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Metoprolol with Oxazepam?
MediHelp rates the interaction as minor. Metoprolol and Oxazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxazepam is cleared by glucuronidation rather than oxidative metabolism, so a meaningful pharmacokinetic interaction with metoprolol is not expected. No clinically important effect has been established.
How serious is the interaction between Metoprolol and Oxazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond usual monitoring of sedation and blood pressure.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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