Drug interactions
Metoprolol + Tadalafil
Severity: Minor
Metoprolol and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil may add modestly to the blood pressure lowering effect of beta blockers such as metoprolol. Dizziness or symptomatic hypotension can occur, although clinically significant effects are generally small.
What this interaction means in plain words
Metoprolol and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metoprolol belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive blood pressure reduction from PDE5-mediated vasodilation and beta-adrenergic blockade.
What to do
No dose change is usually needed. Monitor blood pressure when tadalafil is started and counsel on orthostatic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metoprolol with Tadalafil?
MediHelp rates the interaction as minor. Metoprolol and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tadalafil may add modestly to the blood pressure lowering effect of beta blockers such as metoprolol. Dizziness or symptomatic hypotension can occur, although clinically significant effects are generally small.
How serious is the interaction between Metoprolol and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor blood pressure when tadalafil is started and counsel on orthostatic symptoms.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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