Drug interactions
Metoprolol + Timolol
Severity: Major
Metoprolol and Timolol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol is a non-selective beta-blocker, and combining it with metoprolol duplicates therapy. This increases the risk of bradycardia, hypotension and AV block.
What this interaction means in plain words
Metoprolol and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metoprolol belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Duplicate beta-adrenergic receptor blockade producing additive cardiovascular effects.
What to do
Avoid combining oral beta-blockers and keep one agent at an optimized dose. If both are used, monitor heart rate and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Metoprolol with Timolol?
MediHelp rates the interaction as major. Metoprolol and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Timolol is a non-selective beta-blocker, and combining it with metoprolol duplicates therapy. This increases the risk of bradycardia, hypotension and AV block.
How serious is the interaction between Metoprolol and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining oral beta-blockers and keep one agent at an optimized dose. If both are used, monitor heart rate and blood pressure closely.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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